November 12, 2008

Prevention of breast cancer: making children soon and Sport

“Do children and preferably before 30 years!” That is the message launched by specialists of breast cancer in congress meeting in La Baule, who also stressed the importance of physical activity to prevent this cancer each year involving nearly 50,000 women in France.

Gynecologists, surgeons, oncologists, radiation therapists and other specialists have worked from Wednesday to Friday on the prevention of breast cancer at the 30th Days of the French Society of Senology and Breast Pathology (SFSPM).

Breast CancerThe risk factors are multiple and may interact with each other, making it difficult to develop a “ladder” that would apply to every woman. Some are better prepared than others, starting with age, against which we can not do much, if not to limit other risk factors such as weight gain.

Known protective factors are difficult to change without social support, such as age of first birth or breastfeeding. “Do children, but do young, preferably before 30 years”, launched Francoise Clavel-Chapelon, an epidemiologist at INSERM. As for breastfeeding, it provides “effective protection” but from “5 or 6 years cumulative duration” …

“Everything that was considered by feminists as progress has promoted breast cancer”, summed up the smiling president of the SFSPM Brigitte Séradour.

Exposure to estrogen increases the risk, “recalled specialists. This is the case of hormone replacement therapy for menopause (THMs), but also of alcohol, “which increases the hormonal”.

Oral contraceptives increase the risk a bit, but decrease the risk in return for ovarian cancer. “The pill today is not the same as 20 years ago,” said Pierre Kerbrat, Head of Department of Oncology Center’s fight against cancer Rennes.

The role of food was also discussed, with the final few certainties, if not a diet “high energy density” is limited. If only because it promotes overweight and obesity, clearly established as a risk factor after menopause.

Physical inactivity also appears as a factor promoting breast cancer: 11% of them would be “due,” said Carole Master, gynecologist at the National Sports Institute (INSEP). A majority of studies found a “positive effect” of physical activity as prevention, especially when it is relatively strong and steady.

But what advice prevention can really give girls a woman who developed breast cancer and has a BRCA gene mutation, predisposing gene, questioned the oncologist Elisabeth Luporsi (CAV Nancy ).

For these women “transferred” to “very high risk of developing breast cancer (80% chance), Dr Luporsi raises the question of” chemo-prevention “, carefully targeted to ensure a benefit-risk optimal Taking into account the toxicity of drugs.

The only preventive option for women at high risk is now mastectomy (removal of breasts), increasing in most countries including France.